h-DTP(High-Density Tapping Process)
Filler literally means a “filling material,” a substance injected into subcutaneously fat to correct wrinkles, dents, acne scars and/or facial lines .
Fillers can be classified according to ingredients such as HA, collagen, calcium, PLLA, and etc. Among them, HA fillers are most widely used because of their excellent safety.
HA (Hyaluronic Acid) is a hydrophilic substance, which is also commonly called a natural moisturizer .
It can absorb 1000 times the weight of its weight and has excellent moisture retention It is a 100 % biodegradable and safe component that exists in the human body.
Moisture
1 Molecule of HA attracts 218 water molecules to increase
skin moisture level
Volume
Adjust volume lost depending on the injection depth in
epidermis or dermis
Collagen
Stimulate fibroblast
in dermis for
collagen production
Antioxidant
Remove hazardous
Free Radical created
by UV light
Miraderma is an HA filler with maximized safety, convenience, and effectiveness
based on excellent technology
UHD Technology
STEP 1 .Chemical cross linking
• Minimization of BDDE, a chemical cross linking agent
STEP 2 . Physical Cross linking
• S.THEPHARM’s core production technology to improve viscoelasticity through physical crosslinking
• Realization of safe, high viscoelastic and cohesive filler with low BDDE
• Acquisition of patent for manufacturing technology (KIPO* Patent- 10 – 2186646)
Patented Cross linking Technology that increases the viscoelasticity by improving the internal density at the optimal frequency during the optimal time
(Patent-10 – 2186646)
Disintegration Test
Change over time after injecting 1 ml of hyaluronidase 750 IU into 0.5 ml of
Miraderma retains a big part of its shape 24 hours after hyaluronidase injection, which shows that
it has high viscoelasticity and a long duration compared to other fillers. On the other hand,
48 hours after the injection, it is completely degraded, indicating
that the filler has high purity, resulting in minimized side effects .
CE Approval
Miraderma, cross linked hyaluronic a cid injectable gel with lidocaine, has been recognized for its global quality by obtaining European CE certification that meet s strict safety and environmental standard.
Purification
Purified product yields less side effects due to elimination of residues.
Hyaluronic Acid
BDDE
. Residues
Before Purification
After Purification
Convenience
Safety
Effect
Purified product yields less side effects due to elimination of unreacted materials
▶ Performed ideal washing process to achieve greater safety of the product
- Long washing process allows perfect washing
- Specialized washing process allows consistent product properties (Osmotic pressure, pH)
▶ BDDE Residue is under standard value = Low chance of Allergy, Hypersensitivity
BDDE
Endotoxin
Protein
pH
▶ Reduces side effects such as redness, fever, erythema
▶ Uses ingredients(HA, BDDE, Lidocaine) approved by EDQM
▶ Consistent extrusion force allows smooth injection, therefore, increased convenience.
▶ High viscoelasticity allows to maintain good volume for a long duration
Extrusion Force
Increased convenience due to consistent extrusion force
Viscoelasticity
High viscoelasticity to maintain volume for long durations
PRODUCT NAME
Miraderma Light
Miraderma Deep
Miraderma Shape
PRODUCT
PRODUCT
Moisturizing, Pore tightening
Fine wrinkle correction
Deep wrinkle correction, Volumizing
INDICATION
Full face
Periorbital line, Lip contour
Glabella lines, Nasolabial folds, Marionette lines, Nose/forehead contour
DURATION
Full face
3 - 6 months
6 - 12 months
COMPLEX VISCOSITY
10~100pa·s
100~200pa·s
200~300pa·s
PRODUCT NAME
Miraderma light
PRODUCT
PRODUCT
Moisturizing, Pore tightening
INDICATION
Full face
DURATION
Full face
COMPLEX VISCOSITY
10~100pa·s
PRODUCT NAME
Miraderma Deep
PRODUCT
PRODUCT
Fine wrinkle correction
INDICATION
Periorbital line, Lip contour
DURATION
3 - 6 months
COMPLEX VISCOSITY
100~200pa·s
PRODUCT NAME
Miraderma Shape
PRODUCT
PRODUCT
Deep wrinkle correction, Volumizing
INDICATION
Glabella lines, Nasolabial folds, Marionette lines, Nose/forehead contour
DURATION
6 - 12 months
COMPLEX VISCOSITY
200~300pa·s
Nasolabial folds / QTFILL PLUS DEEP 1cc
Forehead contour / QTFILL PLUS DEEP 1cc
AFTER
Chin volume / QTFILL PLUS SUB-Q 1.5cc
AFTER